曹淑华，女，1973年5月生，民盟盟员，工学博士，教授；现任潍坊学院制药工程教研室主任，西北大学和曲阜师范大学兼职硕士生导师，中国化学会会员，中国化工学会会员，山东省科技专家库入库专家。主要从事荧光染料的生物应用，专注于光动力和化动力试剂及肿瘤诊疗一体化试剂的研发，同时积极与地方企业开展合作研究，为企业解决生产和研发难题。近年来发表高水平SCI论文20多篇。主持教育部产学合作协同育人项目、山东省本科教改项目、潍坊市科技发展计划及横向科研项目等10余项。主持的项目中获潍坊市自然科学奖二等奖1项，三等奖1项，多次被评为潍坊学院优秀教师，2022年获“风筝都最美科技工作者”称号。
招生专业：材料与化工
研究方向：荧光染料的生物应用
联系方式：shuhua@wfu.edu.cn
学术成果：
1.代表性学术论文：
[1] Shuhua Cao, Yuchang Liu, Xishi Tai, Li Shen, Hekai Yang, Fahui Li,
Binglin Sui, Pengju Ma, Lingxuan Zhu, Bin Gao, Anlin Wang*
and Mohammad Azam, A dual-type I/II NIR photosensitizer for effective
cancer photodynamic therapy with enhanced ROS generation, RSC Adv., 2025, 15, 28889-28896.
[2]Shuhua Cao, Xishi Tai, Kaoxue Li, Ailing Zhang, Pengju Ma, Guoqing Sui, Liansong Zhang, Xiaohui Tian, Anlin Wang , Mohammad Azam, Two novel homo/hetero polynuclear complexes for DNA binding, molecular docking and anti-cancer activity, Journal of Molecular Structure, 1325 (2025) 141040.
[3] Weiguo Song, Hekai Yang, Ying Wang, Shuzhen Chen, Wenda Zhong,* Qian Wang, Wenshuo Ding, Guangzhao Xu, Chen Meng, Ying Liang, Zhe-Sheng Chen, Shuhua Cao,* Liuya Wei,* and Fahui Li* Glutathione-Sensitive Photosensitizer-Drug Conjugates Target the Mitochondria to Overcome Multi-Drug Resistance in Cancer, Adv. Sci., 2024, 2307765.
[4]Kaoxue Li, Ailing Zhang, Shuhua Cao* and Jianmin Wang，The crystal structure of tetrakis(μ2-2-amino-3,5-dibromobenzoate-κ2O:O′)-octakis(n-butyl-κ1C)-bis(μ3-oxo)tetratin(II), C60H92Br8N4O10Sn4，Z. Kristallogr. - N. Cryst. Struct. 2024; 239(4): 613-615
[5]Shuhua Cao*, Anlin Wang, Kaoxue Li, Zhiteng Lin, Hongwei Yang,Xiaolei Zhang, Jianmei Qiu and Xishi Tai*，A novel tetranuclear Cu(II) complex for DNA-binding and in vitro anticancer activity, RSC Advances, 2023, 13, 26324-26329.
[6] Qian Wang, Fahui Li*, Hekai Yang, Ying Wang, Wenshuo Ding, Fengxu Dai, Liuya Wei, Shuhua Cao*, and Weiguo Song*, Simultaneously Self-supply of H2O2 and GSH-depleted Intracellular Oxidative Stress for Enhanced Photodynamic /Photothermal /Chemodynamic Therapy, Chem. Commun., 2022, 58, 8536-8540.
[7]Lei Yu, Tingting Zhou, Shuhua Cao, Xishi Tai, Lili Liu, and Yao Wang*, Suppressing the surface passivation of Pt-Mo nanowires via constructing Mo-Se coordination for boosting HER performance, Nano Research, 2021, 14(8): 2659–2665 一区 3/6
[8]Shuhua Cao* ,Fahui Li ，Qian Xu，Meng Yao， Shun Wang， Yunjun Zhou，Xiaotong Cui，Ruolin Man，Kaoxue Li， Xishi Tai* ,Synthesis, crystal structure of a novel tetranuclear Cu (Ⅱ) complex and its application inGSH-triggered generation of reactive oxygen species for chemodynamic therapy，Journal of Saudi Chemical Society . 2021, 25, 101372.
[9]CAO Shu-Hua, TAI Xi-Shi*, XIN Chun-Ling, Synthesis, Crystal Structure and Antitumor Activity of a Ca(II) Coordination Polymer Based on 4-Acetylphenoxyacetate Ligands, Chinese J. Struct. Chem. ,2021, 40(3),324-328.
[10]Shuhua Cao, Xuezhao Li*, Yong Gao, Fahui Li, Kaoxue Li, Xuanxuan Cao,Yiwen Dai, Lirong Mao, Shanshan Wang and Xishi Tai*,A simultaneously GSH-depleted bimetallic Cu(II) complex for enhanced chemodynamic cancer therapy, Dalton Trans., 2020, 49, 11851-11858.
[11]Shuhua Cao*, Jiangli Fan, Wen Sun*, Fahui Li, Kaoxue Li, Xi-Shi Tai and Xiaojun Peng ，A Novel Mn-Cu Bimetallic Complex for Enhanced Chemodynamic Therapy with Simultaneous Glutathione Depletion. Chem. Commun., 2019, 55, 12956--12959.
[12]Kaoxue Li*, Xuhao Yang, Tingting Zhao, Jiaojiao Liu, Jiahui Liu, Yucheng Li, Fahui Li,Xishi Tai, and Shuhua Cao*, Raney Ni as Recyclable and Selective Catalyst for the Reduction of α-Pinene to cis-Pinane with NaBH4 at Room Temperature, ChemistrySelect, 2019, 4, 10506-10509.
[13] .Fengli Gao , Shuhua Cao , Wen Sun , Saran Long , Jiangli Fan , Xiaojun Peng，Development of a two-photon carbazole derivative probe for fluorescent visualization of G-quadruplex DNA in cells. Dyes and Pigments 171 (2019) 107749
[14]Shu-hua Cao*, Fa-hui Li, Li Shen,Study on dispersion stability of copper phthalocyanine (CuPc) blue pigment in water improved by plasma treatments, Journal of Dispersion Scinece and Technology, 2018, VOL. 39, NO. 10, 1417–1421.
[15]Guoqing Sui,*, Lili Shu, Ailing Zhang, Dan Li, and Shuhua Cao*, Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation, Chem. Pharm. Bull. 2024, 72, 186-189.
[16]曹淑华，台夕市产教融合背景下应用型高校制药工程专业实践教学探索高教学刊 2025，19，94-98.
科研项目及获奖
1.涤纶用阻燃剂的开发及中试工艺研究经费30万元，潍坊锦通纺织有限公司 2024.10-2026.09
2.功能染料分散蓝284的开发及中试工艺研究 合同100万元，到账50万元， 潍坊汇韬化工有限公司 2024.05-2025.04
3.功能染料的开发及中试工艺研究横向经费260万元， 潍坊恒彩数码影像材料有限公司 2023.07-2025.06
4.污水应急处置全量化工艺研发与应用 横向 到账经费40万元 山东尚科环境工程有限公司 2022.09-2023.08
5.用于恶劣工况下低温余热发电ORC机组蒸发器的开发及应用横向到账经费 40万元 辉承传热技术（山东）有限公司 2022.05.25起至2025.05.31
6. 靶向蛋白质精氨酸甲基转移酶1的荧光探针的合成及在癌症诊疗中的应用 2019KJHM05 2019.07-2021.06市级 2万主持已结题
7. 几类高活性化合物的合成开发及生物活性研究2019.06-2021.11横向到账经费100万山东道箴医药科技有限公司主持已结题
8. 新型草酰胺桥联多核配合物合成、结构表征及抗肿瘤活性研究，2018GX002，2018.07-2019.12，市级 1万，主持，已结题
9. 石墨烯的制备及其在导电纤维中的应用，2016GX006 2016.07-2017.12 市级 1万 主持 已结题
获奖
1. 新型草酰胺桥联多核配合物的合成、结构表征及抗肿瘤活性研究，潍坊市自然科学奖三等奖第一位 2020.10
2. 靶向蛋白质精氨酸甲基转移酶1的荧光探针的合成及在癌症诊疗中的应用，潍坊市自然科学奖二等奖 第一位 2022.09
3. 抗肿瘤化合物的制备及应用中国技术市场协会金桥奖 4/7 2022.11
4. 硼氢化钠还原烯烃创新工艺在药物合成中的应用，中国技术市场协会金桥奖项目三等奖 2/10 2024.11
